New good metal sights with a squared off edge on the back sight (non-novak style) is an absolute must.  If you try to break open a stuck slide with the factory sights or run 1 handed manipulation drills you'll pop the junk plastic factory sight right out of the dovetail.  I opt for either Ameriglo Operators or Trijicon HD's.  The bright colored front is a huge benefit in picking up your front sight fast.  2nd mod was a Ghost Edge connector.  Made a big difference on the trigger pulls of my 43 and 42.  3rd, stippled the front and back of the grip.  I didn't do the sides as I appendix carry it, but even just the front and back make the gun MUCH better to shoot, especially with wet, cold & numb, or sweaty hands.  Finally, I also undercut the trigger guard.  It makes it more comfortable in the hand and helps avoid that all too common callus on the middle finger knuckle.